Haworth, Brian T. Sutch, Rebecca M. Romero Objectives To evaluate faculty-led discussion meetings (with about eight students) conducted face-to-face (in-class) or by synchronous, real-time videoconference (online), in a biopharmaceutics course taught in a facilitated problem-based learning (PBL) format. Methods Three methods were used to compare in-class versus online discussion sessions for two semesters. The first method involved three parameters that measured the quality of interactions between faculty (facilitator) and student (Fc–St), participation of students in the discussions (Par), and student–student interactions (St–St). The second method assessed student’s perceptions of the discussions with surveys. The third method mapped the interactions (a sociogram) between faculty (facilitator) and students in a discussion. Results There were significantly lower scores for Par and St–St (P < 0.05)>
Physiological purpose and you can pharmacology regarding curcumin
Guide ChapterAsma El-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca Meters. Romero, Ian S Haworth Curcumin is the big part of this new yellow color off turmeric, a keen Indian liven which is obtained from the newest rhizome of one’s tropical plant Curcuma longa, hence is one of the Zingiberaceae family members. Contained in this part, we discuss the pharmacological things out of curcumin and discuss brand new molecular bases of these issues. We up coming remark the brand new demonstrated and potential clinical uses from curcumin. Curcumin is well known usually given that a curative broker, however, its mechanism off step are detail by detail. The new pharmacological negative effects of curcumin appear to be the result of good synergism regarding communities from poor biochemical connections which have several physical purpose when you look at the interconnected signaling paths. This type of targets is enzymes instance cyclooxygenase, lipoxygenase and you can protein kinases, and you can transcription facts eg NF-?B, STAT and you can Nrf2. Modulation ones molecules has an effect on downstream affectors that make the fresh new antiinflammatory, antioxidant, chemopreventive, anticancer, and you may antimicrobial situations of curcumin. These effects have been checked-out during the logical products of curcumin to have pain and you will inflammatory disease, cancer, Alzheimer problem, cardio illness, and you can diabetic issues. The fresh new examples purchased variable doses regarding curcuminwith some other wavelengths and you can period, to your general conclusion you to higher dosages regarding curcumin at quantity of grams must obtain healing outcomes. Read more
Curcumin: Synthesis, Emerging Part when you look at the Problems Management and you can Fitness Ramifications
Publication Chapter Examples of bush-derived pharmaceuticals which have become the appeal of continuous and you may rapid search and advancement interest has actually, to date, come a bit scarce. Immediately after many years, the very last two decades had been described as a beneficial 100-fold increase in the amount of medical blogs wrote annually that was out of importance into usage of curcumin during the biomedicine. Read more
Structure, synthesis and physiological affairs of curcumin prodrugs
Book ChapterAsma El-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca M. Romero, Ian S Haworth Curcumin has some potential pharmacological effects that can possess therapeutic software in several condition says, since discussed in detail in the previous chapter. not, the possibility logical efficacy regarding curcumin is limited of the the physicochemical attributes off terrible drinking water solubility and imbalance, which lead to reduced bioavailability. Prodrugs regarding curcumin offer ways to update of one’s biopharmaceutical and you can pharmacokinetic attributes, that can make it exploitation of your own pharmacological aftereffects LoveFort anmeldelser of curcumin. Within this part, we earliest feedback new physicochemical and you will pharmacokinetics from curcumin. We after that define the style of curcumin prodrugs that have improved liquids solubility and you will enhanced chemical compounds balances which are often converted back to 100 % free curcumin upon bioactivation in the vivo. We emphasize current victory in this area, that have a concentrate on the construction, synthesis and assessment off prodrugs centered on promoieties along with amino acids, fatty acids, nucleic acids, dicarboxylic acids, and you can polymeric material including hyaluronic acid and you may polyethylene glycol. This chapter contains the reason behind optimization of physicochemical and you may biopharmaceutical functions therefore the physiological points from curcumin prodrugs, towards the goal playing with ones curcumin types into the logical software. Read more